| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2022653 | Regulatory Peptides | 2011 | 11 Pages |
Abstract
⺠VS-1 administered i.v. to awake and anesthetized rabbits produces vasoconstrictor and vasodilator effects. ⺠The catecholamine-mediated vasoconstrictor effect predominates in the first 2 h. ⺠A longer-lasting vasodilator effect is unmasked by α-adrenergic blockade. ⺠VS-1 appears to stimulate the release of catecholamines at peripheral level. ⺠The vasodilatory effect, non adrenergic in origin, is consistent with previous reports based on in vitro models.
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Authors
Silvestro Roatta, Magda Passatore, Matteo Novello, Barbara Colombo, Eleonora Dondossola, Mazher Mohammed, Gianni Losano, Angelo Corti, Karen B. Helle,