| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2022905 | Regulatory Peptides | 2009 | 6 Pages |
Abstract
1) B cells are less sensitive to UII at a high glucose level than at a low glucose. 2) The inhibitory effect of UII on both glucose and tolbutamide-induced insulin release, suggests the implication of ATP-dependent K+ channels. The insulinostatic effect of UII was not observed during KCl stimulation, a condition in which these channels are overridden. 3) The insulinostatic effect of UII can also be mediated by its inhibitory action on the adenylate cyclase/cAMP system via a pertussis toxin-sensitive Gi protein.
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Authors
Ramona A. Silvestre, Eva M. Egido, Raquel Hernández, José Marco,