Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2023024 | Regulatory Peptides | 2008 | 4 Pages |
Abstract
Oxytocin is a mammalian hormone that is released mainly after distension of the uterine cervix. In this study, we report that oxytocin stimulates intracellular release of calcium, and also activates AMPK (AMP-activated protein kinase) in C2C12 myoblast cells in a time/dose-dependent manner. Oxytocin receptor mRNA was detected in C2C12 cells. In addition, oxytocin stimulated glucose uptake and, moreover, inhibition of either CaMKK (Ca2+/calmodulin-dependent protein kinase kinase) or AMPK blocked oxytocin-mediated AMPK activation and glucose uptake. Taken together, our findings suggest that oxytocin may serve a peripheral metabolic function in skeletal muscle cells through the calcium–CaMKK–AMPK pathway.
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Authors
Eun Soo Lee, Kyung-Ok Uhm, Yun Mi Lee, Joseph Kwon, Sun-Hwa Park, Kim Hyeon Soo,