Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2023116 | Regulatory Peptides | 2008 | 5 Pages |
Abstract
By using pangenomic microarray, we identified apelin as a unique adipokine up regulated by the transcriptional co-activator peroxisome proliferator-activated receptor γ (PPARγ) co-activator 1α (PGC-1α) in human white adipocytes. We investigated its regulation in vitro and in vivo. Overexpression of PGC-1α by adenovirus in human adipocytes induces apelin expression and secretion. Pharmacological induction of cAMP, an upstream regulator of endogenous PGC-1α expression, up regulates apelin gene expression and also apelin secretion in human and mice adipocytes. Moreover, during cold exposure in mice, a physiological situation known to induce both cAMP and PGC-1α, apelin expression in adipocytes and plasma levels were increased. This is the first demonstration that PGC-1α is involved in the regulation of an adipokine gene expression and release.
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Authors
Anne Mazzucotelli, Carole Ribet, Isabelle Castan-Laurell, Danièle Daviaud, Charlotte Guigné, Dominique Langin, Philippe Valet,