Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2023125 | Regulatory Peptides | 2008 | 7 Pages |
Abstract
The neuropeptide Y (NPY) Y2 receptors and the pancreatic polypeptide Y4 receptors from rabbit kidney cortex are isolated largely as â¼Â 180 kDa complexes constituted of one receptor dimer and one G-protein heterotrimer, similar to NPY receptors expressed in the Chinese hamster ovary (CHO) cells. As expected, kidney and CHO cell Y2 dimers are converted into monomers by increasing concentrations of a selective agonist. Prevalence of dimeric Y2 receptors in the kidney could be related to low plasma levels of Y2 agonists, and possibly also to a relatively low concentration of Gi α subunits.
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Authors
A.M. Estes, Y.Y. Wong, M.S. Parker, F.R. Sallee, A. Balasubramaniam, S.L. Parker,