| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2023596 | Seminars in Cancer Biology | 2015 | 9 Pages |
Abstract
Quality control systems in the endoplasmic reticulum (ER) mediated by unfolded protein response (UPR) and endoplasmic reticulum associated degradation (ERAD) ensure cellular function and organismal survival. Recent studies have suggested that ER quality-control systems in cancer cells may serve as a double-edged sword that aids progression as well as prevention of tumor growth in a context-dependent manner. Here we review recent advances in our understanding of the complex relationship between ER proteostasis and cancer pathology, with a focus on the two most conserved ER quality-control mechanisms-the IRE1α-XBP1 pathway of the UPR and SEL1L-HRD1 complex of the ERAD.
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Authors
Hana Kim, Asmita Bhattacharya, Ling Qi,