Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2023608 | Seminars in Cancer Biology | 2015 | 7 Pages |
Abstract
Cancer is a clonal malignant disease originated in a single cell and characterized by the accumulation of partially differentiated cells that are phenotypically reminiscent of normal stages of differentiation. According to current models, therapeutic strategies that block oncogene activity are likely to selectively target tumor cells. However, recent evidences have revealed that cancer stem cells could arise through a tumor stem cell reprogramming mechanism, suggesting that genetic lesions that initiate the cancer process might be dispensable for tumor progression and maintenance. This review addresses the impact of these results toward a better understanding of cancer development and proposes new approaches to treat cancer in the future.
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Authors
Carolina Vicente-Dueñas, Julia Hauer, Lucía Ruiz-Roca, Deborah Ingenhag, Alba Rodríguez-Meira, Franziska Auer, Arndt Borkhardt, Isidro Sánchez-García,