| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2023622 | Seminars in Cancer Biology | 2015 | 7 Pages |
Abstract
DNA damaging agents (ionizing radiation and chemotherapeutics) are considered as most effective in cancer treatment. However, there is a subpopulation of carcinoma cells within the tumour demonstrating resistance to DNA damaging treatment approaches. It is suggested that limited tumour response to this kind of therapy can be associated with specific molecular properties of carcinoma stem cells (CSCs) representing the most refractory cell subpopulation. This review article presents novel data about molecular features of CSCs underlying DNA damage response and related intracellular signalling.
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Authors
Sergej Skvortsov, Paul Debbage, Peter Lukas, Ira Skvortsova,