Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2023727 | Seminars in Cancer Biology | 2013 | 8 Pages |
Abstract
Recent evidence has uncovered cross-regulation of mechanisms of cell engulfment by proteins of the autophagy pathway, in what is called LC3-Associated Phagocytosis, or LAP. By LAP, lysosome fusion to phagosomes and the degradation of engulfed extracellular cargo are facilitated by autophagy proteins that lipidate LC3 onto phagosome membranes. Here we discuss the contexts where LAP is known to occur by focusing on potential roles in tumorigenesis, including predicted consequences of LAP inhibition.
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Authors
Sung Eun Kim, Michael Overholtzer,