Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2023761 | Seminars in Cancer Biology | 2012 | 5 Pages |
Abstract
Epithelial to mesenchymal transition (EMT) during metastasis is initially a two-step process beginning with delamination of cells from the solid tumor followed by acquisition of a migratory phenotype. Several reports indicate that plasma membrane blebbing, associated with cell division, coincides with cell delamination during developmental EMT. This raises a speculative question if blebbing drives EMT in cancer cells in a similar way. Here, we review available data on factors and processes that may support such a connection.
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Authors
Petra Sekyrova, Joel Östblom, Michael Andäng,