Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2023767 | Seminars in Cancer Biology | 2012 | 6 Pages |
Abstract
The epithelial-to-mesenchymal transition (EMT) is an important event converting compact and ordered epithelial cells into migratory mesenchymal cells. Given the molecular and cellular similarities between pathological and developmental EMTs, studying this event during neural crest development offers and excellent in vivo model for understanding the mechanisms underlying this process. Here, we review new and old insight into neural crest EMT in search of commonalities with cancer progression that might aid in the design of specific therapeutic prevention.
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Authors
Pablo H. Strobl-Mazzulla, Marianne E. Bronner,