Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2023808 | Seminars in Cancer Biology | 2007 | 13 Pages |
Abstract
The cell of origin of cancer has been a strongly debated topic through out the history of cancer research. This review provides a historic framework and a synopsis of how the theories of cancer initiation and progression evolved from early times to the present day. We present the concept of a cancer stem cell, and review for you the literature supporting the existence of cancer stem cells in addition to a brief discussion on our own work supporting a bone marrow-derived source for the cancer stem cell, as well as cells of the cancer stroma.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
JeanMarie Houghton, Alexei Morozov, Iva Smirnova, Timothy C. Wang,