| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2023814 | Seminars in Cancer Biology | 2007 | 7 Pages |
Abstract
Human neuroblastoma is an embryonic cancer of the neural crest. Cellular heterogeneity is a characteristic feature of both tumors and derived cell lines. Recent studies have revealed that both cell lines and tumors contain cancer stem cells. In culture, these cells are self-renewing, multipotent, and highly malignant; in tumors their frequency correlates with a worse prognosis. Their identification and characterization should now permit a targeted approach to more effective treatment of this often fatal childhood cancer.
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Authors
Robert A. Ross, Barbara A. Spengler,