Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2023849 | Seminars in Cancer Biology | 2007 | 7 Pages |
Abstract
Among unusual models to study cell death mechanisms, the protist Dictyostelium is remarkable because of its strategic phylogenetic position, with early emergence among eukaryotes and unicellular/multicellular transition, and its very favorable experimental and genetic flexibility. Dictyostelium shows developmental vacuolar cell death, and in vitro monolayer approaches revealed both an autophagic vacuolar and a necrotic type of cell death. These are described in some detail, as well as implications and future prospects.
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Authors
Emilie Tresse, Artemis Kosta, Marie-Françoise Luciani, Pierre Golstein,