Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2023935 | Seminars in Cancer Biology | 2006 | 11 Pages |
Abstract
14-3-3 proteins are a family of highly conserved cellular proteins that play key roles in the regulation of central physiological pathways. More than 200 14-3-3 target proteins have been identified, including proteins involved in mitogenic and cell survival signaling, cell cycle control and apoptotic cell death. Importantly, the involvement of 14-3-3 proteins in the regulation of various oncogenes and tumor suppressor genes points to a potential role in human cancer. The present review summarizes current findings implicating a 14-3-3 role in cancer while discussing potential mechanisms and points of action of 14-3-3 during cancer development and progression.
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Authors
Guri Tzivion, Vinita Singh Gupta, Ludmila Kaplun, Vitaly Balan,