Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2023936 | Seminars in Cancer Biology | 2006 | 11 Pages |
Abstract
The 14-3-3σ gene is a direct target of the p53 tumor suppressor and its product inhibits cell cycle progression. Recently, a proteomic analysis revealed that 14-3-3σ regulates additional cellular processes relevant to carcinogenesis, as migration and MAP-kinase signalling. The expression of 14-3-3σ is down-regulated by CpG methylation in several types of human cancer, among them prostate, lung, breast and several types of skin cancer. The epigenetic inactivation of 14-3-3σ occurs at an early stage of tumor development and may allow evasion from senescence and promote genomic instability. In the future the detection of CpG methylation of 14-3-3σ may be used for diagnostic and prognostic purposes.
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Authors
Dmitri Lodygin, Heiko Hermeking,