Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2024097 | Seminars in Cancer Biology | 2007 | 10 Pages |
Abstract
Naïve CD8 T cells respond to signals provided by Ag, costimulation and cytokines by proliferating and differentiating to develop effector functions. Following initial clonal expansion, however, the cells develop activation-induced non-responsiveness (AINR), a form of anergy characterized by an inability to produce IL-2. Cells in the AINR state can carry out effector functions (cytolysis, IFN-γ production) but cannot continue to proliferate and expand in the face of persisting Ag. AINR limits the ability of activated CTL to control tumor growth but can be reversed by IL-2, provided either therapeutically or by activated CD4 T helper cells, to allow continued expansion.
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Authors
Matthew F. Mescher, Flavia E. Popescu, Michael Gerner, Chris D. Hammerbeck, Julie M. Curtsinger,