Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2024126 | Seminars in Cancer Biology | 2006 | 8 Pages |
Abstract
While there is now little debate about the existence or relevance of regulatory populations of T cells to a variety of human diseases, including cancer, there is considerable debate about the ontogeny, phenotype, and mechanisms of action of given regulatory T cell populations. This review will limit itself to discussion to two distinct populations of CD4+ regulatory T cells: T cells co-expressing the CD25 receptor (Tregs), and type 1 regulatory (Tr1) T cells. Attention will be focused on the definition and role of these regulatory T cell populations in human cancers.
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Authors
Clare Baecher-Allan, David E. Anderson,