| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2024137 | Seminars in Cancer Biology | 2010 | 13 Pages |
Abstract
Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutation instability or PIN) in carcinogenesis.
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Authors
Bradley D. Preston, Tina M. Albertson, Alan J. Herr,