Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2024217 | Seminars in Cancer Biology | 2007 | 14 Pages |
Abstract
DNA copy number amplifications activate oncogenes and are found in the majority of advanced solid tumors. Cell-lineage specificity and oncogene affinity of DNA amplifications in cancer suggest that properties of precursor stem cells and selection pressure in the tissue micro-environment determine the genomic location of gene amplifications. Biological specificity and significance of gene amplifications make them potential targets for clinical applications. Here we discuss the specificity of non-randomly occurring DNA copy number amplifications as defining features for cancers, their selection in the tumor tissue, and significance in the clinical practice.
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Authors
Samuel Myllykangas, Tom Böhling, Sakari Knuutila,