Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2024221 | Seminars in Cancer Biology | 2007 | 11 Pages |
Abstract
Chromosomal translocations and genomic instability are universal hallmarks of tumor cells. While the molecular mechanisms leading to the formation of translocations are rapidly being elucidated, a cell biological understanding of how chromosomes undergo translocations in the context of the cell nucleus in vivo is largely lacking. The recent realization that genomes are non-randomly arranged within the nuclear space has profound consequences for mechanisms of chromosome translocations. We review here the emerging principles of spatial genome organization and discuss the implications of non-random spatial genome organization for the genesis and specificity of cancerous chromosomal translocations.
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Authors
Karen J. Meaburn, Tom Misteli, Evi Soutoglou,