First synthesis of 22-oxa-chenodeoxycholic acid analogue

•We have firstly succeeded in synthesizing the 22-oxa-CDCA analogue from androstenedione and progesterone, respectively.•The synthesis was achieved in 11 and 8 steps with overall yields of 6.4% and 12.7%, respectively.•This study provides an access towards the development of CDCA analogues as new drugs.

In this study, we report the first synthesis of 22-oxa-chenodeoxycholic acid analogue via androstenedione and progesterone, in 11 and 8 steps with overall yields of 6.4% and 12.7%, respectively. We anticipate this will help to facilitate the development of new drugs.

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