Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2027631 | Steroids | 2016 | 8 Pages |
•For the first time catalytic cycloalumination of (3β,5α)-3-vinylcholestane and (3α,5α)-3-allylcholestane were accomplished.•Efficient syntheses of novel steroidal cyclic organoaluminum compounds.•A convenient one-pot method for cyclopentanone and S,Se-heterocycle moiety formation on steroid.•The structures of all novel compounds were confirmed by NMR measurements.
Catalytic cycloalumination of (3β,5α)-3-vinylcholestane and (3α,5α)-3-allylcholestane with Et3Al catalyzed by Cp2ZrCl2 was performed for the first time to give previously unknown aluminacyclopentanes in ∼90% yield; these products were converted in situ to carbo- and heterocyclic (5α)-cholestane derivatives.
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