Synthesis and evaluation of asiatic acid derivatives as anti-fibrotic agents: Structure/activity studies

•11 new compounds which are not mentioned on other journals are discovered.•All those new compounds were tested through “Effect of asiatic acid derivatives”.•The data presented may be useful in the design of novel anti-fibrotic agents.

Fibrotic diseases are characterized by the over-accumulation of fibrous components in the extracellular matrix and the liver, which can lead to liver cirrhosis. Current treatment options cannot reverse or halt liver fibrosis, motivating a search for newer treatment options. Previously, we showed that asiaticoside, a bioactive triterpene glycoside from Centella asiatica, has anti-fibrotic properties. Here, the aglycone asiatic acid was chemically modified, and these derivatives were evaluated for their potential as anti-fibrotic agents. The data obtained from in vivo testing of these compounds in a rodent CCl4-induced liver injury model are discussed. The information obtained from these studies may be useful in the design of novel anti-fibrotic agents.

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