Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2027780 | Steroids | 2015 | 6 Pages |
Abstract
Besides generating immunocompetent T lymphocytes, the thymus is an established site of de novo extra-adrenal glucocorticoid (GC) production. Among the compartments of the thymus, both stromal thymic epithelial cells (TECs) and thymocytes secrete biologically active GCs. Locally produced GCs secreted by the various thymic cellular compartments have been suggested to have different impact on thymic homeostasis. TEC-derived GCs may regulate thymocyte differentiation whereas thymocyte-derived GCs might regulate age-dependent involution. However the full biological significance of thymic-derived GCs is still not fully understood. In this review, we summarize and describe recent advances in the understanding of local GC production in the thymus and immunoregulatory steroid production by peripheral T cells and highlight the possible role of local GCs for thymus function.
Keywords
ACTHNF-κBNFATPKBPKCGREHSDTCrTECDllMAPKSteroidogenesisInvolutioninterferonIFNinterleukinT cell differentiationsingle positiveThymusThymocytesDouble negativedouble positiveThymic epithelial cellsthymic epithelial cellNuclear Factor of Activated T Cellsglucocorticoid responsive elementsnuclear factor κBdelta-like ligandmajor histocompatibility complexMHCHPA-axisHypothalamus-pituitary-adrenal axisadrenocorticotropic hormoneprotein kinase BProtein kinase Cmitogen activated protein kinaseGlucocorticoidGlucocorticoidsT cell receptorglucocorticoid receptor
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Authors
Gergely Talaber, Mikael Jondal, Sam Okret,