Three novel degraded steroids from cultures of the Basidiomycete Antrodiella albocinnamomea

•Three novel degraded C21 sterols with a new γ-lactone or lactol ring.•The absolute configuration of 1 was determined.•The mixture of compounds 2 and 3 could inhibit PTP1B.

Three novel degraded steroids, named albocisterols A–C (1–3), have been isolated from cultures of Antrodiella albocinnamomea. Their structures were defined by comprehensive spectroscopic analysis and single crystal X-ray crystallography. The mixture of compounds 2 and 3 exhibited significant inhibitory activities against protein tyrosine phosphatase 1B (PTP1B).

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