An efficient route for annulation of pyrimidines to steroids and non-steroids via a base catalyzed one-pot three component reaction

•Steroidal A- and D-ring fused pyrimidines were synthesized.•KOtBu catalyzed multi-component reaction provided the products.•Cyclic ketone, aromatic aldehyde and amidine were the starting materials.•Reactions were performed in ethanol under reflux conditions.

A facile strategy for the synthesis of steroidal A- and D-ring fused pyrimidines has been accomplished in high yields via a one-pot reaction of steroidal ketones, aromatic aldehydes and amidine derivatives in presence of potassium tert-butoxide in refluxing ethanol. The generality of the reaction was also extended to non-steroidal ketones.

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