| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2027936 | Steroids | 2013 | 6 Pages |
There were synthesized new types of ribbon type steroidal dimers derived from three types of steroidal skeletons (cholic acid, etienic acid, estrone) using CuI catalyzed 1, 3-dipolar cycloaddition reaction. Steroid parts of the molecular “ribbons” are linked by heterocyclic moiety, namely by 2,6-bis((1H-1,2,3-triazol-1-yl)-methyl)pyridine. Compounds synthesized possess different cytotoxic and hormone receptor modulating activities.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► New types of ribbon type steroidal dimers synthesized using 1,3-dipolar cycloaddition reaction. ► Reaction linked by heterocyclic moiety, namely by 2,6-bis((1H-1,2,3-triazol-1-yl)methyl)pyridine. ► Compounds synthesized possess different cytotoxic and hormone receptor modulating activities.
