| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2027981 | Steroids | 2012 | 5 Pages |
Three new steroids 3-oxocholest-1,22-dien-12β-ol (1), 3-oxocholest-1,4-dien-20β-ol (2), 3-oxocholest-1,4-dien-12β-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4) [7a], 5α,8α-Epidioxycholesta-6,22-dien-3β-ol (5) [10] and 5-cholestene-3β,12β-diol (6) [11] were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC50’s 14 and 15 μM.
► Three new steroids 1–3 were isolated from a marine organism Dendronephthya gigantea. ► Relative stereochemistry was elucidated by the analysis of HRMS and 2-D NMR. ► New steroids 1 and 2 showed potent inhibitory activity against FXR.
