Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2028056 | Steroids | 2012 | 5 Pages |
Bioactivity-guided separation of the aqueous methanolic extract of Yucca desmettiana leaves, which in a preliminary screening exhibited significant molluscicidal activity, led to the isolation and structure elucidation of two new steroidal saponins (1 and 2). The structures of desmettianosides A and B, identified as bisdesmosidic furostanol glycosides with six and five sugar units, respectively, were established by detailed spectroscopic analyses of their NMR and MS data. Compounds 1 and 2 exhibited high molluscicidal activity against Biomphalaria alexandrina snails with LC100 values of 6 and 11 mg/L, respectively.
► The aqueous methanolic extract of Yucca desmettiana leaves was investigated. ► Two new compounds were isolated and identified as bisdesmosidic furostanol saponins. ► The sugar chains consisted of five and six units (galactose, glucose and xylose). ► The saponins exhibited high activity against Biomphalaria alexandrina snails. ► The LC100 values of the isolated saponins were 6 and 11 mg/L.