Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2028073 | Steroids | 2013 | 9 Pages |
Abstract
⺠Stat3, PR and ErbB-2 are necessary for progestin-induced upregulation of p21CIP1. ⺠Progestin recruits Stat3, PR and ErbB-2 to a Stat3 binding site on p21CIP1 promoter. ⺠ErbB-2 acts as a coactivator of Stat3 in progestin-induced p21CIP1 transcription. ⺠p21CIP1 is essential for progestin-induced breast cancer growth.
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Authors
MarÃa C. Diaz Flaqué, RocÃo Vicario, Cecilia J. Proietti, Franco Izzo, Roxana Schillaci, Patricia V. Elizalde,