Article ID Journal Published Year Pages File Type
2028078 Steroids 2013 10 Pages PDF
Abstract
► A single high dose of estradiol (E2) given acutely after ischemia protects brain. ► Aging hippocampus remains responsive to acute E2 effects. ► Post-treatment is effective even after long-term hypoestrogenicity. ► Some non-feminizing estrogen analogs also promote cell survival. ► Acute E2 effects are mediated by membrane initiated E2 signaling.
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