| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2028107 | Steroids | 2011 | 4 Pages |
A Pd-C-catalyzed hydrogenation in methanol and in the presence of sodium methylate is a simple, convenient and high yielding reduction method to convert the 7,14-dien-6-one ecdysteroids to their corresponding 7,8α-dihydro-14α-deoxyecdysteroids.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A Pd-C-catalyzed hydrogenation in the presence MeONa is a simple, convenient and high yield reduction method to convert the 7,14-dien-6-one ecdysteroids into 7,8α-dihydro-14α-deoxyecdysteroids. ► We have developed a selective procedure for the reduction of the double bonds of steroid skeleton and side chain of ecdysteroids via catalytic hydrogenation in methanol in the presence of sodium methoxide. ► The molecules structure of the obtained compounds was unambiguously proved by a single X-ray diffraction study.
