Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2028159 | Steroids | 2010 | 11 Pages |
Abstract
Sixteen new and one known metabolites 4–20 were obtained by incubation of tibolone (1) and hydroxytibolones (2 and 3) with various fungi. Their structures were elucidated by means of a homo and heteronuclear 2D NMR and by HREI-MS techniques. The relative stereochemistry was deduced by 2D NOESY experiment. Metabolites of tibolone (1) exhibited significant inhibitory activities against α-glucosidase and tyrosinase enzymes. Hydroxylations at C-6, C-10, C-11, C-15 positions and α,β-unsaturation at C-1/C-2, C-4/C-5 showed potent inhibitory activities against these enzymes.
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Authors
M. Iqbal Choudhary, S. Adnan Ali Shah, Atta-ur-Rahman, Shamsun-Nahar Khan, Mahmud Tareq Hassan Khan,