| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2028173 | Steroids | 2013 | 11 Pages |
Abstract
Estrogenicity assay: Methanol extract of S. nitens (Sn) and xanthones 2, 5, 3 and 4 were significantly different (â) from negative control (DMSO) (α = 0.05) and were considered estrogenic in the recombinant yeast assay (RYA). Antimutagenicity assay (Ames test): All the isolated compounds displayed more strong antimutagenic activity for TA100, reaching the inhibiting 62% (1); 55% (2); 51% (3); 89% (5); 69% (6); 75% (7); 85% (8) and 75% (9) of the mutagenic effect of aflatoxin B1. 4 showed more significantly results for TA98 and inhibited 54% of the mutagenicity caused by benzo[a]pyrene. âConcentrations that were significantly different from positive controls (TA100: Aflatoxin B1; TA98: benzo[a]pyrene) (α = 0.05).
Keywords
FAPESPHSCCCBAWEriocaulaceaeHRTryaCNPqEEQNPD17β-estradiolAFB1DMSOSERMsAflatoxin B1DESEstrogenicitystandard deviationRecombinant yeast assayMutagenicityDimethylsulfoxideMethanol extractHexane extractphytoestrogensLuteolinSelective estrogen receptor modulatorsAntimutagenicityultraviolet lighthormone replacement therapyEstrogen receptor
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Authors
Ana Paula Siqueira de Oliveira, Juliana Ferreira de Sousa, Marcelo Aparecido da Silva, Felipe Hilário, Flávia Aparecida Resende, Mariana Santoro de Camargo, Wagner Vilegas, Lourdes Campaner dos Santos, Eliana Aparecida Varanda,