Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2028181 | Steroids | 2013 | 7 Pages |
Abstract
•Key reactions include a diastereoselective OTMS cyanohydrin reaction and aldol.•Synthesis of C17 estrone analogs possessing alkyl and aryl substituted α,β-unsaturated ketones.•Synthesis of C24 thioether estrone analogs via a sulfa-Michael addition reaction of p-thiocresolto an enone.
Functionalized estrogen analogs have received interest due to their unique and differing biological activity compared to their parent compounds. The synthesis of a new class of 3-methoxyestrone analogs functionalized at the C17 position possessing both alkyl and aryl substituted α,β-unsaturated ketones is described, along with their thiophenol conjugate addition products.
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Authors
Lucas C. Kopel, Mahmoud S. Ahmed, Fathi T. Halaweish,