Article ID Journal Published Year Pages File Type
2028238 Steroids 2012 5 Pages PDF
Abstract

Using cholesterol as starting material, some steroidal lactone compounds with the structures of 3-substituted-6-oxo-7-oxa-B-homo-cholestane or 3-substituted-7-oxo-6-oxa-B-homo-cholestane were synthesized by oxidation, reduction, Baeyer–Villiger reaction and condensation reaction. The cytotoxicity of these compounds against MGC 7901 (human gastric carcinoma), HeLa (human cervical carcinoma) and SMMC 7404 (human liver carcinoma) cells was investigated. Our results showed that the synthesized compounds displayed a distinct cytotoxicity against these cancer cells. In particular, compounds 8 and 9 have similar cytotoxic capability as cisplatin does. The information obtained from the studies may be useful for the design of novel chemotherapeutic drugs.

► A new series of B-homo-lactone derivatives of cholestane was synthesized. ► The synthesized compounds displayed a distinct cytotoxicity. ► The cytotoxicity of compounds 8 and 9 is similar to cisplatin’s. ► The 8 remarkably increased its cytotoxicity in comparison with its precursor.

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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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