Article ID Journal Published Year Pages File Type
2028359 Steroids 2010 9 Pages PDF
Abstract
▶ Most cardenolides and bufadienolides inhibit the sodium pump non-selectively. ▶ A synthetic bufadienolide lacking the 14-OH inhibits the sodium pump selectively. ▶ Emicymarin is a weaker inhibitor of the leucocyte than the erythrocyte sodium pump. ▶ Selectivity may explain the symptomless pump inhibition seen in human hypertension.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Authors
, , , , , , ,