| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2028425 | Steroids | 2009 | 4 Pages |
Abstract
An efficient method to prepare 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione in one pot was reported. Treatment of 9-bromide-11-hydroxypregna-1, 4, 16-trien-3, 20-dione with Raney Ni in absolute ethanol afforded 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione by two annulation reactions in reasonable yield. The absolute configuration was also confirmed by X-ray crystal analysis.
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Authors
Ping Jia, Xuling Wu, Yongping Yu, Guolin Zhang,