| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2028430 | Steroids | 2009 | 8 Pages |
Abstract
The synthesis of several novel 5α- and 5β-20-oxo-pregnane derivatives substituted in the position 3 and 7 of the steroid skeleton is described. Activity of synthesized compounds was studied in voltage-clamped cultured rat hippocampal neurons. Substituted derivatives inhibited NMDA-elicited neuronal activity. The relationship between biological activity and structure is discussed.
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Authors
Eva Stastna, Hana Chodounska, Vladimir Pouzar, Vojtech Kapras, Jirina Borovska, Ondrej Cais, Ladislav Vyklicky Jr.,