New vernocuminosides from the stem barks of Vernonia cumingiana Benth

Seven new stigmastane-type steroidal glycosides, vernocuminosides A–G (1–7), have been isolated from the stem barks of Vernonia cumingiana Benth. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods including 1D and 2D NMR (1H–1H COSY, HSQC, HMBC, and NOE) experiments, especially the employment of Snatzke’s method expressed by the induced circular dichroism spectra. Anti-inflammatory activities and cytotoxicities of compounds 1–7 were evaluated.