Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2028493 | Steroids | 2011 | 7 Pages |
We have monitored the effect of ergosterol on electrical capacitance and electrical resistance of the phosphatidylcholine bilayer membranes using chronopotentiometry method. The chronopotentiometric characteristic of the bilayers depends on constant-current flow through the membranes. For low current values, no electroporation takes place and the membrane voltage rises exponentially to a constant value described by the Ohm's law. Based on these kinds of chronopotentiometric curves, a method of the membrane capacitance and the membrane resistance calculations is presented.
► The effect of ergosterol on capacitance and resistance of the phosphatidylcholine membranes. ► Application of chronopotentiometry to the research of lipid bilayers. ► Simple and precise estimation of membrane parameters.