Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2028639 | Steroids | 2009 | 6 Pages |
Abstract
A simple approach to a stable steroidal estrone derived A,B-spiro system is reported. Treatment of estrone derived A-ring diepoxyalcohol with the Ac2O–TMSOTf system at the ambient temperature led to acetylation, while at the reflux temperature the acid-catalysed rearrangement took place affording the spiro-compound. Results of extensive in vitro and in vivo anticancer tests on the diepoxide, as well as preliminary data on the antiproliferative activity of the spiro-product against three cancer cell lines, are also presented.
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Authors
Dragana Milic, Tatjana Kop, Janos Csanadi, Zorica Juranic, Zeljko Zizak, Miroslav J. Gasic, Bogdan Solaja,