| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2028674 | Steroids | 2011 | 5 Pages |
Two new withanolides, philadelphicalactone C (1) and philadelphicalactone D (4), along with the known withaphysacarpin (3), ixocarpanolide (5), philadelphicalactone A (6), and ixocarpalactone A (7) were isolated from the aerial parts of Physalis philadelphica Lam. Structures of these compounds were determined by spectroscopic analyses and that of philadelphicalactone C (1) was confirmed by X-ray crystallographic analysis. Evaluation of the cytotoxic activity of all isolates and the derivative 2 against a panel of human cancer cell lines indicated a potent activity of compounds 2, 3, 6, and 7.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Two new and four known withanolides were isolated from Physalis philadelphica. ► The new compounds are 24-hydroxywithanolides. ► Five of the isolated compounds showed cytotoxic activity against a panel of six human cancer cell lines. ► Withaphysacarpin (3) showed the most potent cytotoxicity with IC50 values <1.0 μM in five of the cell lines. ► The diacetyl derivative of 1 also showed a strong activity.
