Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2028686 | Steroids | 2008 | 6 Pages |
Abstract
Five new steroids, namely griffinisterones F-I (1-4) and griffinipregnone (5) have been isolated from the octocoral Dendronephthya griffini. The structures of these compounds were elucidated by extensive spectroscopic analysis. Compounds 1-3 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the LPS-stimulated RAW264.7 macrophage cells at 10 μM. At the same concentrations 2 also could significantly inhibit the accumulation of the pro-inflammatory COX-2 protein.
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Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Chih-Hua Chao, Zhi-Hong Wen, Jui-Hsin Su, I-Ming Chen, Ho-Cheng Huang, Chang-Feng Dai, Jyh-Horng Sheu,