Microwave (MW) irradiated Ugi four-component reaction (Ugi-4CR): Expedited synthesis of steroid–amino acid conjugates – A novel class of hybrid compounds

•We report here the application of MW energy in Ugi 4CR.•We report here synthesis of steroid–peptide conjugates by MW assisted Ugi 4CR.•We report here a very fast and high yield method for synthesizing steroid–peptide conjugates.•We report here much superior method for synthesis of steroid–peptide conjugates over the existing method.•WE report here a clean high yield fast method for synthesizing steroid peptide conjugates.

Microwave (MW) assisted chemical reactions are currently gaining considerable importance in organic synthesis to contribute in green technology. Considering the importance of peptidomimetic steroid–amino acid conjugates – a novel class of hybrid compounds having diverse biological properties, we report here synthesis of these compounds of alanine and valine methyl esters with seco-steroids (A, B and D ring cleavage) in expedited way by MW promoted Ugi-four-component reaction (Ugi-4CR).

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