| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2029290 | Steroids | 2011 | 9 Pages |
Abstract
⺠The effects of glucocorticoids on cartilage and bone cells in vitro. ⺠Glucocorticoids have a protective effect against cartilage degradation and a tendency to increase cartilage formation. ⺠Glucocorticoids also have detrimental effects on the bone cells. ⺠Glucocorticoids may be used for intra-articular injections in treatment of OA, if bone damage could be impaired simultaneously.
Keywords
M-CSFα-MEMOPGIGF-ITRAPRANKLBMP-2OSMDEXPBSsGAGMMPPREDOsteoarthritisOsteoblastsOsteoprotegerinOsteoclaststartrate-resistant acid phosphataseoncostatin MELISAEnzyme-linked immunosorbent assaytumor necrosis factor-αDexamethasoneinsulin-like growth factor 1TNF-αPhosphate buffered salinematrix metalloproteinasemacrophage colony-stimulating factorEx vivo modelPrednisolonebone morphogenetic protein 2ChondrocytesGlucocorticoidSulfated glycosaminoglycansreceptor activator of nuclear factor kappa-B ligand
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Authors
Suzi H. Madsen, Kim V. Andreassen, Søren T. Christensen, Morten A. Karsdal, Francis M. Sverdrup, Anne-Christine Bay-Jensen, Kim Henriksen,