Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2029395 | Steroids | 2009 | 5 Pages |
Abstract
Three new (1–3) and several known (4–6) steroids were isolated from the leaves of Chinese Melia azedarach. The structures of the new compounds were elucidated by means of spectroscopic methods including 2D NMR techniques and mass spectrometry to be (20S)-5,24(28)-ergostadiene-3β,7α,16β,20-tetrol (1), (20S)-5-ergostene-3β,7α,16β,20-tetrol (2), and 2α,3β-dihydro-5-pregnen-16-one (3). The cytotoxicities of the isolated compounds against three human cancer cell lines (A549, H460, U251) were evaluated; only compounds 1, 2, and (20S)-5-stigmastene-3β,7α,20-triol (4) were found to show significant cyctotoxic effects with IC50s from 12.0 to 30.1 μg/mL.
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Authors
Shi-Biao Wu, Yan-Ping Ji, Jing-Jing Zhu, Yun Zhao, Gang Xia, Ying-He Hu, Jin-Feng Hu,