| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2029507 | Steroids | 2008 | 9 Pages |
Abstract
The synthesis of two “glycospirostanes” from 23-oxotigogenin acetate is described. (23S,24S,25R)-5α-Spirostane-3β,23,24,25-tetraol was obtained by dehydrogenation followed by stereoselective reduction of the 23-oxo group and OsO4 dihydroxylation of the C24–C25 double bond. Allylic hydroxylation with SeO2 of 3β-acetoxy-5α-spirost-23-ene obtained from 23-oxotigogenin acetate followed by OsO4 dihydroxylation of the C23–C24 double bond afforded (23R,24S,25R)-5α-spirostane-3β,23,24,25-tetraol.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Yliana López, Izabella Jastrzębska, Rosa Santillan, Jacek W. Morzycki,