Article ID Journal Published Year Pages File Type
2029518 Steroids 2007 5 Pages PDF
Abstract

Ergosterimide (1), a natural Diels–Alder adduct of ergosteroid and maleimide, was characterized from the culture extract of Aspergillus niger EN-13, an endophytic fungus isolated from the marine brown alga Colpomenia sinuosa. In addition, four known steroids including (22E,24R)-ergosta-5,7,22-trien-3β-ol (2), (22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (3), (22E,24R)-5α,8α-epidioxyergosta-6,22-dien-3β-ol (4), and (22E,24R)-ergosta-7,22-dien-3β,5α,6β-triol (5) were also isolated and identified. The structures of these compounds were elucidated by extensive analysis of 1D and 2D NMR and IR spectra and MS data. The plausible biosynthetic pathway of 1 was also discussed. To the best of our knowledge, 1 is the first natural Diels–Alder adduct of steroid and maleimide reported so far.

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